Anabolic SteroidsSparse/variable compound-specific evidence

Clostebol

Clostebol is listed in current U.S. federal Schedule III regulations as an anabolic steroid or covered anabolic-steroid substance. Compound-specific human evidence may be limited or historical.

Last reviewed: 2026-08-09
Safety context

Nonmedical use can involve serious endocrine, cardiovascular, hepatic and reproductive risks.

Regulatory / research statusFederally Schedule III anabolic steroid in the United States.

At a glance

Clostebol is listed in current U.S. federal Schedule III regulations as an anabolic steroid or covered anabolic-steroid substance. Compound-specific human evidence may be limited or historical.

  • Chemical designation: 4-chloro-17β-hydroxyandrost-4-en-3-one
  • Evidence: Sparse/variable compound-specific evidence
  • U.S. federal status: Federally Schedule III anabolic steroid in the United States.

Pharmacology

Anabolic-androgenic steroids act primarily through the androgen receptor. Tissue effects depend on the parent steroid, metabolites, route, exposure, aromatization or 5α-reduction characteristics, and individual biology. A chemical listing by itself does not establish a safe or effective use.

Evidence and medical context

For many older or designer anabolic steroids, modern controlled human evidence is sparse. Where a compound has had therapeutic use, the clinical evidence and approved labeling should not be extrapolated to bodybuilding-style exposure. LiftLab intentionally distinguishes established medical evidence from historical claims and gym folklore.

Safety

Class-level evidence associates nonmedical androgen exposure with suppression of the hypothalamic-pituitary-gonadal axis, infertility and hypogonadism, adverse lipid changes, hypertension and cardiovascular toxicity, erythrocytosis in some contexts, acne/androgenic effects, mood or psychiatric effects in some users, and compound-dependent liver injury. Risk varies substantially by agent and exposure.

Regulatory note

Under current U.S. federal regulations, anabolic steroids meeting the statutory definition are Schedule III controlled substances. State law and sport-governing rules may add additional restrictions.

What this page does not provide

This encyclopedia does not provide cycles, stacks, injection instructions, post-cycle protocols, sourcing advice, or individualized dosing. Clinical study exposure, when discussed elsewhere on LiftLab, is presented only to describe the research design.

References

  1. 21 CFR §1308.13 — Schedule III anabolic steroids
  2. Anabolic–androgenic steroids: mechanisms and adverse effects (PubMed)
  3. Androgen abuse: risks and adverse effects in men (PubMed)
This page is an educational reference, not individualized medical advice. Inclusion of a compound is not endorsement. LiftLab does not provide nonmedical cycles, stacks, sourcing, injection instructions or personalized dosing.

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